Jia J, Jiang J
Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
Cell Mol Life Sci. 2006 Jun;63(11):1249-65. doi: 10.1007/s00018-005-5519-z.
The Hedgehog (Hh) family of secreted proteins plays essential roles in a myriad of developmental processes via a complex signaling cascade conserved in species ranging from insects to mammals. In many developmental contexts, Hh acts as long-range morphogen to control distinct cellular outcomes as a function of its concentration. Here we review the current understanding of the Hh signaling mechanisms that govern the establishment of the Hh gradient and the transduction of the Hh signal with an emphasis on the intracellular signaling cascade from the receptor to the nuclear effector. We discuss how graded Hh signals are transduced to govern distinct developmental outcomes.
分泌蛋白的刺猬（Hh）家族通过昆虫到哺乳动物等物种中保守的复杂信号级联，在无数发育过程中发挥着重要作用。在许多发育情况下，Hh作为长距离形态发生素，根据其浓度控制不同的细胞结果。在这里，我们综述了目前对Hh信号传导机制的理解，这些机制控制着Hh梯度的建立和Hh信号的转导，重点是从受体到核效应器的细胞内信号级联。我们讨论了分级Hh信号如何被转导以控制不同的发育结果。
