Bohn M C, Howard E, Vielkind U, Krozowski Z
Department of Neurobiology and Anatomy, University of Rochester Medical Center, NY 14642.
J Steroid Biochem Mol Biol. 1991;40(1-3):105-11. doi: 10.1016/0960-0760(91)90173-3.
In the brain, the action of glucocorticoid steroids is mediated via two intracellular receptors, the mineralocorticoid (MR), or type I receptor, and the glucocorticoid (GR), or type II receptor. These receptors are expressed in many types of neurons and are co-expressed in some neurons such as the hippocampal pyramidal cells. Although glucocorticoids are known to affect gliogenesis and glial cell differentiation, the expression of the GR in different types of glial cells throughout the brain has not been thoroughly studied and the expression of the MR in glia not previously reported. Here we review studies suggesting that both receptors are expressed in astrocytes and oligodendrocytes.
在大脑中，糖皮质激素的作用是通过两种细胞内受体介导的，即盐皮质激素受体（MR）或I型受体，以及糖皮质激素受体（GR）或II型受体。这些受体在多种类型的神经元中表达，并且在一些神经元（如海马锥体细胞）中共同表达。尽管已知糖皮质激素会影响神经胶质生成和神经胶质细胞分化，但GR在全脑不同类型神经胶质细胞中的表达尚未得到充分研究，而MR在神经胶质细胞中的表达此前也未见报道。在此，我们综述了一些研究，这些研究表明这两种受体均在星形胶质细胞和少突胶质细胞中表达。
