Ji Xiu-Ling, Jin Gui-Wen, Qu Li-Ya, Cheng Jin-Ping, Wang Wen-Hua
School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
Huan Jing Ke Xue. 2006 Jan;27(1):142-5.
In order to survey the potential health risk of environmental exposure by mercury, Sprague-Dawley rats were reared by mercury contaminated rice from mercury mining area. The changes of neurotransmitter acetylcholine (ACh) and acetylcholinesterase (AChE) in rat brain were examined at different times. The results show that the mercury-contaminated rice significantly increase the content of ACh in rat brain after exposure for 7 days. ACh maintained at a high level even after exposure for 30 days, but decreased significantly after exposure for 90 days. The changes of AChE represented an inverse trend compared with that of ACh. The coexisting selenium in rice exhibited antagonistic effects on both mercury accumulation and toxicity. The findings suggested that neurotoxic effects of environmental mercury contamination had been significantly represented after chronically dietary exposure. Further studies are needed to examine the relationship between the neurotransmitter level changes and the Alzheimer's Disease (AD).
为了调查汞环境暴露的潜在健康风险，用汞矿区受汞污染的大米饲养Sprague-Dawley大鼠。在不同时间检测大鼠脑中神经递质乙酰胆碱（ACh）和乙酰胆碱酯酶（AChE）的变化。结果表明，受汞污染的大米在暴露7天后显著增加大鼠脑中ACh的含量。即使在暴露30天后ACh仍维持在高水平，但在暴露90天后显著下降。AChE的变化与ACh呈相反趋势。大米中同时存在的硒对汞的积累和毒性均表现出拮抗作用。研究结果表明，长期饮食暴露后环境汞污染的神经毒性作用已得到显著体现。需要进一步研究来探讨神经递质水平变化与阿尔茨海默病（AD）之间的关系。
