Cowen P J, McCance S L, Ware C J, Cohen P R, Chalmers J S, Julier D L
Psychopharmacology Research Unit, Littlemore Hospital, Oxford.
Br J Psychiatry. 1991 Sep;159:341-6. doi: 10.1192/bjp.159.3.341.
The addition of lithium to the tricyclic antidepressant medication of 23 patients with major depression resulted in an increase in the prolactin response to intravenous L-tryptophan after both four days and four weeks of treatment. The extent of this increase did not distinguish the ten patients who were classified as clinical responders (greater than 50% reduction in score on the HRSD). Among the responders there was a modestly significant correlation between the decrease in score on the HRSD and the enhancement of tryptophan-induced prolactin release. Some responders, however, showed very little change in this endocrine response over the four weeks of lithium treatment. Lithium may increase brain 5-HT function in tricyclic-resistant depression but there is only limited support for the hypothesis that changes in brain 5-HT function are involved in the antidepressant effect of this treatment combination.
在23名重度抑郁症患者的三环类抗抑郁药物治疗中加入锂盐，结果显示，在治疗4天和4周后，静脉注射L-色氨酸所引起的催乳素反应均有所增加。这种增加的程度并不能区分出被归类为临床反应者的10名患者（汉密尔顿抑郁量表评分降低超过50%）。在反应者中，汉密尔顿抑郁量表评分的降低与色氨酸诱导的催乳素释放增强之间存在适度显著的相关性。然而，一些反应者在锂盐治疗的四周内，这种内分泌反应变化很小。锂盐可能会增加对三环类药物耐药的抑郁症患者大脑中的5-羟色胺功能，但关于大脑5-羟色胺功能变化参与这种联合治疗的抗抑郁作用这一假说，仅有有限的支持证据。
