Hwang Chi-Shin
Department of Neurology, Taipei City Hospital, (Zongxiao Branch), Taiwan.
Acta Neurol Taiwan. 2006 Mar;15(1):26-8.
This case was a 27 years old female with severe acute respiratory syndrome (SARS). She suffered from typical symptoms of SARS. Although she got almost complete recovery from most symptoms after treatment, she noted acute onset complete anosmia 3 weeks after the onset of her first symptom. Her brain MRI examination did not show definite lesion except an incidental finding of left temporal epidermoid cyst. Her anosmia persisted for more than 2 years during following up. Peripheral neuropathy and myopathy have been reported as a concomitant problem during the convalescent stage of SARS, while the sequel of permanent ansomia in SARS was not reported before. Olfactory neuropathy, which rarely occurred in typical peripheral neuropathy, could be a special type of neuropathy induced by corona virus infection in SARS. Olfactory function test should be taken into routine check-up for patients with SARS. The pathophysiology and therapeutic strategy of this special type of permanent olfactory dysfunction deserve further investigation.
该病例为一名27岁患有严重急性呼吸综合征（SARS）的女性。她出现了SARS的典型症状。尽管经治疗后她的大多数症状几乎完全康复，但她在出现首个症状3周后出现急性起病的完全嗅觉丧失。她的脑部MRI检查除偶然发现左侧颞叶表皮样囊肿外未显示明确病变。在随访期间，她的嗅觉丧失持续了2年多。外周神经病变和肌病已被报道为SARS恢复期的伴随问题，而SARS导致永久性嗅觉丧失的后遗症此前未见报道。嗅觉神经病变很少发生在典型的外周神经病变中，可能是SARS中冠状病毒感染诱发的一种特殊类型的神经病变。对于SARS患者，嗅觉功能测试应纳入常规检查。这种特殊类型的永久性嗅觉功能障碍的病理生理学和治疗策略值得进一步研究。
