Perlman Sharon, Vaisbuch Edi, Ben-Arie Alon
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University and Hadassah Medical School, Jerusalem, Israel.
Harefuah. 2006 Mar;145(3):219-22, 244.
Breast cancer is the most common cancer among women in the western world. The dramatic change in mortality due to breast cancer in the last decade was associated with better screening for early detection of malignancy and improved hormonal anti-estrogenic adjuvant therapy, mainly Tamoxifen. However, in the endometrium, Tamoxifen has a proestrogenic effect. Among women treated with Tamoxifen, a wide range of endometrial pathologies was documented--from polyps and hyperplasia to malignant tumors. Hence, there is still a debate on the character of malignant tumors developing under the influence of Tamoxifen treatment. Moreover, there are no clear guidelines considering the evaluation of the endometrium in women treated by Tamoxifen. These issues are discussed in this review.
乳腺癌是西方世界女性中最常见的癌症。过去十年间，乳腺癌死亡率的显著变化与恶性肿瘤早期检测的更好筛查以及激素抗雌激素辅助治疗（主要是他莫昔芬）的改善有关。然而，在子宫内膜中，他莫昔芬具有雌激素样作用。在接受他莫昔芬治疗的女性中，记录了多种子宫内膜病变——从息肉、增生到恶性肿瘤。因此，关于在他莫昔芬治疗影响下发生的恶性肿瘤的性质仍存在争议。此外，对于接受他莫昔芬治疗的女性子宫内膜评估，没有明确的指导方针。本综述将对这些问题进行讨论。
