Borenstein Amy R, Mortimer James A, Wu Yougui, Jureidini-Webb Fern M, Fallin M Daniele, Small Brent J, Mullan Michael, Crawford Fiona C
Department of Epidemiology and Biostatistics, College of Public Health, MDC-56, University of South Florida, 13201 Bruce B. Downs Boulevard, Tampa, FL 33612-3805, USA.
Ethn Dis. 2006 Winter;16(1):9-15.
To compare relative frequencies of apolipo-protein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with five cognitive measures. The APOE-epsilon4 allele frequency was 29.5% in African Americans and 12.1% in Caucasians. In the African Americans, no association was found between the presence of the APOE-epsilon4 allele and any of the cognitive measures. Among Caucasians, APOE-epsilon4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-epsilon4 allele in our African-American sample compared to other US-based studies.
为了比较非裔美国人和高加索人群中载脂蛋白E（APOE）等位基因的相对频率，并测试其与认知的关联，我们研究了两个基于社区的样本：一个由253名非裔美国人组成，另一个由466名年龄在60 - 84岁的高加索人组成。采用逻辑回归分析，对年龄、性别、教育程度以及高血压和糖尿病病史进行校正，以研究APOE与五项认知指标之间的关联。非裔美国人中APOE-ε4等位基因频率为29.5%，高加索人中为12.1%。在非裔美国人中，未发现APOE-ε4等位基因的存在与任何认知指标之间存在关联。在高加索人中，APOE-ε4携带者在五项测试中的三项表现较差。我们还报告，与其他基于美国的研究相比，我们的非裔美国人样本中APOE-ε4等位基因的频率要高得多。
