Lin Xiao-jing, Luo Bing-de, Li Ya-jie, Zhao Zhi-rong, Tan Qing, Wang Bin
Southern Hospital, Southern Medical University, Guangzhou 510515, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Mar;24(3):164-6.
To observe the change in vital signs and arterial blood gas in Lipopolysaccharide (LPS)-injected heat exposed rats.
Male pathogen-free Wistar rats were randomly assigned to the following groups: saline-injected normothermic control (C-Group), saline-injected heat exposed (H-Group), LPS-injected normothermic control (L-Group), LPS-injected heat exposed (HL-Group). Rectal temperature (Tr), heart rate (HR), mean arterial pressure (MAP), arterial blood gas were continually monitored.
(1) The rats in HL-Group displayed significantly high values of Tr (43.04 degrees C +/- 0.11 degrees C) and HR [(660 +/- 42) beats/min] and low values of MAP [(49.0 +/- 3.5) mm Hg] compared with C-Group. There was a significant difference in the values of Tr, HR, and MAP between HL-Group and L-Group and in the values of HR and MAP between HL-Group and H-Group. (2) The values of PaO(2), HCO(3)(-), PaCO(2) were significantly lower than those in C-Group at 40 min after LPS-injected heat stress. At 120 min, the PaO(2) [(11.59 +/- 1.11) kPa], HCO(3)(-) [(10.42 +/- 1.06) mmol/L], PaCO(2) [(2.82 +/- 0.81) kPa] in HL-Group were significantly lower than those in L-Group. A significant difference in the values of HCO(3)(-) and PaCO(2) between HL-Group and H-Group was also observed.
LPS-injected heat stress primes the rat to advance and augment the change in vital signs, arterial blood gas, and systemic inflammatory response syndrome.
观察注射脂多糖（LPS）的热暴露大鼠生命体征及动脉血气的变化。
将雄性无特定病原体Wistar大鼠随机分为以下几组：注射生理盐水的常温对照组（C组）、注射生理盐水的热暴露组（H组）、注射LPS的常温对照组（L组）、注射LPS的热暴露组（HL组）。持续监测直肠温度（Tr）、心率（HR）、平均动脉压（MAP）及动脉血气。
（1）与C组相比，HL组大鼠的Tr（43.04℃±0.11℃）和HR[（660±42）次/分钟]显著升高，MAP[（49.0±3.5）mmHg]显著降低。HL组与L组之间Tr、HR和MAP值存在显著差异，HL组与H组之间HR和MAP值存在显著差异。（2）注射LPS热应激后40分钟，HL组的PaO₂、HCO₃⁻、PaCO₂值显著低于C组。120分钟时，HL组的PaO₂[（11.59±1.11）kPa]、HCO₃⁻[（10.42±1.06）mmol/L]、PaCO₂[（2.82±0.81）kPa]显著低于L组。HL组与H组之间HCO₃⁻和PaCO₂值也存在显著差异。
注射LPS的热应激促使大鼠生命体征、动脉血气及全身炎症反应综合征的变化提前并加剧。
