Vogel Ida, Thorsen Poul, Hundborg Heidi Holmager, Uldbjerg Niels
NANEA, Institute for Public Health, Department of Epidemiology, University of Aarhus, Vennelyst Boulevard 6, 8000 Aarhus C, Denmark.
Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):113-8. doi: 10.1016/j.ejogrb.2005.11.002. Epub 2005 Dec 6.
To examine serum relaxin as a predictor of spontaneous preterm delivery.
A prospective study of 2846 women with singleton pregnancies, from which a matched case-control study (84 cases of spontaneous preterm delivery before 37 weeks gestation and 175 controls) and a cohort (84 preterm and 399 term deliveries) were extracted.
In the women with a subsequent preterm delivery the relaxin level decreased by 0.9% per week as compared to 1.9% per week (t-test, p=0.004) in the women with term deliveries. From the cohort the course of S-relaxin during pregnancy in both preterm and term deliveries were fitted and graphed. S-relaxin level was raised in women who were hormonally stimulated to obtain pregnancy (p=0.0001), and lower in women with pre-pregnancy overweight (BMI> or =25, p=0.01) as well as in women, who had previously been pregnant (p=0.008). A longitudinal adjusted model for the prediction of preterm delivery based on the change in S-relaxin was established.
S-relaxin levels decrease less rapidly in women who subsequently deliver preterm; this results in elevated S-relaxin levels in the second and the third trimesters.
研究血清松弛素作为自然早产预测指标的作用。
对2846名单胎妊娠女性进行前瞻性研究，从中提取出一项匹配病例对照研究（84例妊娠37周前自然早产病例和175例对照）以及一项队列研究（84例早产和399例足月分娩）。
与足月分娩女性每周1.9%的下降幅度相比，随后发生早产的女性松弛素水平每周下降0.9%（t检验，p = 0.004）。根据队列研究结果，对早产和足月分娩女性孕期的S - 松弛素变化过程进行拟合并绘图。通过激素刺激受孕的女性S - 松弛素水平升高（p = 0.0001），孕前超重女性（BMI≥25，p = 0.01）以及有过孕产史的女性S - 松弛素水平较低（p = 0.008）。基于S - 松弛素变化建立了预测早产的纵向校正模型。
随后发生早产的女性S - 松弛素水平下降速度较慢；这导致孕中期和孕晚期S - 松弛素水平升高。
