Nilsson B M, Hultman C M, Wiesel F-A
Department of Neuroscience, Psychiatry, Uppsala University Hospital, Uppsala SE-75017, Sweden.
Prostaglandins Leukot Essent Fatty Acids. 2006 May;74(5):339-46. doi: 10.1016/j.plefa.2006.02.002. Epub 2006 Apr 4.
Patients with schizophrenia have in different studies shown reduced niacin sensitivity and lower electrodermal activity (EDA) after auditory stimulation. Peripheral mediation of prostaglandins may have a physiological role in both responses. This motivates study of both niacin response and electrodermal responding in the same patients with schizophrenia. Thirty patients with schizophrenia and 17 controls were investigated with EDA and thereafter given 200mg niacin orally with continuous assessment of skin temperature. The patients showed a delayed temperature increase after niacin ingestion (P=0.002) and a higher frequency of electrodermal non-responding (P<0.05). Response/non-response for niacin correlated with EDA response/non-response in the patient group (P=0.009). The niacin test revealed a slower vasodilation reaction in the patients. The association between response patterns for the niacin test and EDA suggests that a common aberration in skin physiology may be of importance for both reactions in schizophrenia.
在不同研究中，精神分裂症患者在听觉刺激后表现出烟酸敏感性降低和皮肤电活动（EDA）降低。前列腺素的外周介导可能在这两种反应中都具有生理作用。这促使我们对同一组精神分裂症患者的烟酸反应和皮肤电反应进行研究。对30名精神分裂症患者和17名对照者进行了皮肤电活动研究，之后口服200毫克烟酸，并持续监测皮肤温度。患者在摄入烟酸后体温升高延迟（P = 0.002），皮肤电无反应的频率更高（P < 0.05）。患者组中烟酸反应/无反应与皮肤电活动反应/无反应相关（P = 0.009）。烟酸试验显示患者的血管舒张反应较慢。烟酸试验反应模式与皮肤电活动之间的关联表明，皮肤生理的共同异常可能对精神分裂症的这两种反应都很重要。
