Motoo Y, Sawabu N, Nakanuma Y
Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Liver. 1991 Oct;11(5):272-7. doi: 10.1111/j.1600-0676.1991.tb00529.x.
Expression of epidermal growth factor (EGF) and fibroblast growth factor (FGF) was examined in 56 patients with hepatocellular carcinoma (HCC) using an immunohistochemical method. EGF and FGF were expressed on carcinoma cells in 14 (25%) and 23 cases (41%), respectively. In the 23 FGF-positive cases, 11 cases were positive for both acidic and basic FGF, while 18 were positive for acidic FGF, and 16 were positive for basic FGF. In non-cancerous hepatic tissues, FGF was weakly positive in macrophages, hepatocytes and vascular endothelial cells in some cases, while EGF was totally negative. There were no significant correlations between the expression of EGF or FGF on carcinoma cells and the various clinicopathologic factors examined. These data suggest that EGF and FGF are produced by human HCC cells in vivo. The roles of the expression of these growth factors in the development and progression of HCC remain only speculative.
采用免疫组织化学方法检测了56例肝细胞癌（HCC）患者中表皮生长因子（EGF）和成纤维细胞生长因子（FGF）的表达情况。EGF和FGF分别在14例（25%）和23例（41%）的癌细胞中表达。在23例FGF阳性病例中，11例酸性和碱性FGF均为阳性，18例酸性FGF阳性，16例碱性FGF阳性。在非癌性肝组织中，FGF在某些病例的巨噬细胞、肝细胞和血管内皮细胞中呈弱阳性，而EGF完全阴性。癌细胞中EGF或FGF的表达与所检测的各种临床病理因素之间无显著相关性。这些数据表明，EGF和FGF在体内由人HCC细胞产生。这些生长因子表达在HCC发生发展中的作用仍只是推测性的。
