Kelly K, Kane M A, Bunn P A
Division of Medical Oncology, University of Colorado Cancer Center, Denver 80262.
Med Pediatr Oncol. 1991;19(6):450-8. doi: 10.1002/mpo.2950190602.
Growth factors play an important role in the pathogenesis and progression of all histologic types of lung cancer. Ideas for the exploitation of growth factors in lung cancer management are growing. The inhibition of the interaction between growth factors and their receptors, utilization of negative growth factors, interruption of the signal transduction pathways, or effecting decreased growth factor and/or receptor expression, could result in cell death, and all seem logical possibilities for new and specific treatment approaches. There can be no question that observations of the abnormal expression of growth factors have made a startling impact in every aspect of cancer research. The elucidation of their role in cell proliferation, coupled with our growing knowledge of the functions of oncogenes, has given birth to a unifying concept for the etiology of malignant transformation, which hopefully will translate into new, less toxic, more effective, and desperately needed lung cancer treatment.
生长因子在所有组织学类型肺癌的发病机制和进展过程中发挥着重要作用。利用生长因子进行肺癌治疗的想法日益增多。抑制生长因子与其受体之间的相互作用、利用负性生长因子、中断信号转导通路，或促使生长因子和/或受体表达降低，都可能导致细胞死亡，而所有这些似乎都是新的特异性治疗方法的合理可能性。毫无疑问，生长因子异常表达的观察结果在癌症研究的各个方面都产生了惊人的影响。对其在细胞增殖中作用的阐明，再加上我们对癌基因功能的不断了解，催生了一个关于恶性转化病因的统一概念，有望转化为新的、毒性更小、更有效且急需的肺癌治疗方法。
