肾脏的功能磁共振成像：肾脏疾病病理生理学转化研究的工具
Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease.
作者信息
Prasad Pottumarthi V
机构信息
Dept. of Radiology, Walgreen Jr. Bldg., Suite 507, Evanston Northwestern Healthcare, 2650 Ridge Ave., Evanston, IL 60201, USA.
出版信息
Am J Physiol Renal Physiol. 2006 May;290(5):F958-74. doi: 10.1152/ajprenal.00114.2005.
Abstract
Magnetic resonance imaging (MRI) provides exquisite anatomic detail of various organs and is capable of providing additional functional information. This combination allows for comprehensive diagnostic evaluation of pathologies such as ischemic renal disease. Noninvasive MRI techniques could facilitate translation of many studies performed in controlled animal models using technologies that are invasive to humans. Such a translation is being recognized as essential because many proposed interventions and drugs that prove efficacious in animal models fail to do so in humans. In this article, we review the state-of-the-art functional MRI technique as applied to the kidneys.
摘要
磁共振成像（MRI）能提供各种器官精细的解剖细节，并且能够提供额外的功能信息。这种结合使得对诸如缺血性肾病等病症进行全面的诊断评估成为可能。非侵入性MRI技术可以促进许多在使用对人类具有侵入性的技术的对照动物模型中所进行的研究的转化。这种转化被认为是至关重要的，因为许多在动物模型中证明有效的拟议干预措施和药物在人类中却未能如此。在本文中，我们综述了应用于肾脏的最新功能MRI技术。
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