Hillemacher Thomas, Bayerlein Kristina, Wilhelm Julia, Frieling Helge, Sperling Wolfgang, Kornhuber Johannes, Bleich Stefan
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
Neuropsychobiology. 2006;53(3):133-6. doi: 10.1159/000092543. Epub 2006 Apr 4.
Prolactin secretion is closely connected to dopaminergic transmission that is known to play a crucial role in mediating reinforcement and craving in alcoholism.
The study was performed to analyze the association between prolactin serum levels and alcohol craving during withdrawal differentiating alcohol-dependent patients using Lesch's typology.
We assessed 115 male patients with the Obsessive Compulsive Drinking Scale at early alcohol withdrawal. In addition, serum was obtained to measure prolactin concentration and the patients were classified according to Lesch's typology into one of four subgroups.
Correlation analysis showed a significant association between prolactin serum levels and the extent of craving in Lesch's type 2 patients (r=0.32, p=0.015; n=57); however, no association was found for any other subgroup. The results were confirmed comparing patients with low and high craving (Mann-Whitney U test: Z=-2.805, p=0.005).
In patients of Lesch's type 2, who are characterized to suffer from anxiety and to use alcohol because of its anxiolytic effects, prolactin is associated with craving during early alcohol withdrawal.
催乳素分泌与多巴胺能传递密切相关，已知多巴胺能传递在介导酒精中毒的强化和渴望方面起着关键作用。
本研究旨在分析戒酒期间催乳素血清水平与酒精渴望之间的关联，使用莱施分类法区分酒精依赖患者。
我们在早期酒精戒断时用强迫性饮酒量表评估了115名男性患者。此外，采集血清以测量催乳素浓度，并根据莱施分类法将患者分为四个亚组之一。
相关性分析显示，莱施2型患者的催乳素血清水平与渴望程度之间存在显著关联（r = 0.32，p = 0.015；n = 57）；然而，在任何其他亚组中均未发现关联。比较渴望程度低和高的患者，结果得到证实（曼-惠特尼U检验：Z = -2.805，p = 0.005）。
在莱施2型患者中，其特点是患有焦虑症并因酒精的抗焦虑作用而饮酒，催乳素与早期酒精戒断期间的渴望有关。
