Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Neuropsychopharmacol Rep. 2021 Sep;41(3):352-361. doi: 10.1002/npr2.12182. Epub 2021 May 7.
Prolactin mirrors the dopaminergic activity in the brain which is key to understanding alcohol use disorders (AUD). Still, patients with AUD are a heterogenous group and there seem to be gender differences in the relationship between alcohol use and the level of prolactin. In this study, we examined gender-wise relationship of alcohol use trait- and state-related factors with the level of prolactin among AUD inpatients in remission.
This cross-sectional study examined the level of prolactin along with general patient characteristics and alcohol use trait- and state-related factors that could influence the level of prolactin in 112 AUD inpatients at three rehabilitation clinics in Norway. Logistic regression was performed to identify the gender-specific predictors of level of prolactin.
Male and female AUD patients had similar level of prolactin. Among females, younger age, early alcohol debut, and absence of parental drinking problem predicted higher level of prolactin. In males, presence of other substance dependence predicted a lower level of prolactin.
There were gender differences in the factors associated with the level of prolactin among the AUD patients. Especially in the female AUD patients under remission, alcohol use trait-related factors were better predictors of the level of prolactin than the alcohol use state-related factors, indicating that individuals might characteristically have varying degree of dopamine reactivity.
催乳素反映了大脑中的多巴胺活性，这对于理解酒精使用障碍（AUD）至关重要。然而，AUD 患者是一个异质群体，并且在酒精使用与催乳素水平之间的关系中似乎存在性别差异。在这项研究中，我们检查了在缓解期 AUD 住院患者中，性别相关的酒精使用特质和状态相关因素与催乳素水平之间的关系。
这项横断面研究检查了 112 名在挪威三个康复诊所的 AUD 住院患者的催乳素水平以及一般患者特征和可能影响催乳素水平的酒精使用特质和状态相关因素。使用逻辑回归确定催乳素水平的性别特异性预测因素。
男性和女性 AUD 患者的催乳素水平相似。在女性中，年龄较小、早期饮酒开始和无父母饮酒问题预测催乳素水平较高。在男性中，存在其他物质依赖预测催乳素水平较低。
在 AUD 患者中，与催乳素水平相关的因素存在性别差异。特别是在缓解期的女性 AUD 患者中，与酒精使用状态相关的因素相比，酒精使用特质相关因素是催乳素水平更好的预测因素，这表明个体可能具有不同程度的多巴胺反应性。
