McAfee William J, Morris Christopher G, Amdur Robert J, Werning John W, Mendenhall William M
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
Am J Clin Oncol. 2006 Apr;29(2):168-70. doi: 10.1097/01.coc.0000203759.94019.76.
To update our experience with definitive radiotherapy (RT) for juvenile nasopharyngeal angiofibroma (JNA).
Twenty-two patients received definitive RT for advanced JNA between June 1975 and March 2003 and were followed from 2.0 to 30.2 years (median, 12.7 years). Total dose ranged from 30 to 36 Gy.
Twenty of 22 patients (91%) remained locally controlled after RT; both patients who developed a local recurrence were salvaged so that the ultimate local control rate was 100%. No patient experienced a severe complication.
Patients with advanced and/or recurrent JNA thought not to be amenable to complete resection with acceptable morbidity have a high likelihood of cure after RT with a low risk of complications.
更新我们对青少年鼻咽血管纤维瘤（JNA）进行根治性放疗（RT）的经验。
1975年6月至2003年3月期间，22例晚期JNA患者接受了根治性放疗，并随访了2.0至30.2年（中位时间为12.7年）。总剂量范围为30至36 Gy。
22例患者中有20例（91%）放疗后局部得到控制；2例出现局部复发的患者均成功挽救，最终局部控制率为100%。无患者发生严重并发症。
对于那些被认为无法通过可接受的低发病率进行完整切除的晚期和/或复发性JNA患者，放疗后治愈的可能性很高，且并发症风险较低。
