Lee Jivianne T, Chen Peter, Safa Afshin, Juillard Guy, Calcaterra Thomas C
Division of Head and Neck Surgery, UCLA Medical Center, Los Angeles, California 90095-1624, U.S.A.
Laryngoscope. 2002 Jul;112(7 Pt 1):1213-20. doi: 10.1097/00005537-200207000-00014.
OBJECTIVES/HYPOTHESIS: To demonstrate the efficacy of external beam radiation therapy as a primary treatment modality for the management of patients with advanced juvenile nasopharyngeal angiofibroma (JNA).
Retrospective chart review.
The medical records of 130 patients with the diagnosis of JNA seen at UCLA Medical Center over a 41-year period (1960-2000) were retrospectively reviewed.
One hundred thirty cases of JNA have been seen at UCLA Medical Center from 1960 to 2000. One hundred two were treated with surgical resection, 1 refused therapy, and the remaining 27 received radiation (3000-5500 cGy) as their primary mode of treatment. Fifteen percent (4 of 27) of the irradiated patients developed recurrent tumor 2 to 5 years later. Long-term complications occurred in 4 patients (15%) and consisted of growth retardation, panhypopituitarism, temporal lobe necrosis, cataracts, and radiation keratopathy.
External beam radiation therapy represents an effective mode of treatment for patients with advanced JNA. Although the latency period may be long, we think the likelihood of potentially fatal complications developing at the radiation dosages we recommend is less than the risk of significant morbidity and mortality associated with surgical intervention in these cases.
目的/假设：证明外照射放疗作为晚期青少年鼻咽血管纤维瘤（JNA）患者主要治疗方式的疗效。
回顾性病历审查。
回顾性审查了在41年期间（1960 - 2000年）于加州大学洛杉矶分校医学中心就诊的130例诊断为JNA患者的病历。
1960年至2000年期间，加州大学洛杉矶分校医学中心共诊治了130例JNA患者。102例接受了手术切除，1例拒绝治疗，其余27例接受放疗（3000 - 5500 cGy）作为主要治疗方式。15%（27例中的4例）接受放疗的患者在2至5年后出现肿瘤复发。4例患者（15%）出现长期并发症，包括生长发育迟缓、全垂体功能减退、颞叶坏死、白内障和放射性角膜病。
外照射放疗是晚期JNA患者的一种有效治疗方式。尽管潜伏期可能较长，但我们认为在我们推荐的放射剂量下发生潜在致命并发症的可能性低于这些病例中与手术干预相关的严重发病率和死亡率风险。
