Niimura Fumio, Kon Valentina, Ichikawa Iekuni
Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Curr Opin Pediatr. 2006 Apr;18(2):161-6. doi: 10.1097/01.mop.0000193288.56528.40.
Recognition of the dramatically expanded functional repertoire of the renin-angiotensin system now includes a role in morphogenesis of the kidney and urinary tract. On the basis of published data, the article presents formulations of mechanisms through which the system operates.
Studies in humans and animals carrying defective angiotensin-related genes have provided unequivocal evidence that the renin-angiotensin system is involved in the normal development of both the kidney and the urinary tract. Angiotensin exerts its function through at least two different types of receptors, AT1 and AT2. AT1 mediates establishment of the ureteral peristaltic machinery, while AT2 mediates the early kidney and urinary tract morphogenesis. Disruption in receptor functions promotes development of congenital anomalies of the kidney and urinary tract.
Angiotensin is involved in multiple steps of normal development of the kidney and urinary tract through two types of receptors. This takes place in concert with other functionally overlapping genes.
目前已认识到肾素-血管紧张素系统的功能范围显著扩大，其中包括在肾脏和尿路形态发生中的作用。基于已发表的数据，本文阐述了该系统发挥作用的机制。
对携带缺陷性血管紧张素相关基因的人类和动物的研究提供了明确证据，表明肾素-血管紧张素系统参与肾脏和尿路的正常发育。血管紧张素通过至少两种不同类型的受体（AT1和AT2）发挥作用。AT1介导输尿管蠕动机制的建立，而AT2介导早期肾脏和尿路的形态发生。受体功能的破坏会促进肾脏和尿路先天性异常的发展。
血管紧张素通过两种类型的受体参与肾脏和尿路正常发育的多个步骤。这与其他功能重叠的基因协同发生。
