Brock J W, Hunley T E, Adams M C, Kon V
Department of Pediatric Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
J Urol. 1998 Nov;160(5):1812-9.
The role of the renin-angiotensin system in the homeostasis of fluid, electrolyte and blood pressure has been known for quite some time. Recent developments indicate that angiotensin has a profound role, not only in the developing urinary tract but also in the response of the urinary tract to injury. In this review we outline these characteristics.
We summarize the clinical approach to congenital abnormalities of the kidney and urinary tract, and report new data obtained in genetically engineered mice. Furthermore, we present the connection between the mutant mice observations and human congenital abnormalities.
Genetically engineered mutants clearly indicate that the renin-angiotensin system is important for normal renal and urological development. As in glomerular disease, the renin-angiotensin system is involved in progressive damage due to urological disease.
While the renin-angiotensin system is important for blood pressure regulation, it also affects the embryogenesis of the urinary tract and modulates renal injury due to specific disease processes. The importance of angiotensin and its blockade provides an exciting avenue for possible early treatment in children with congenital anomalies of the kidney and urinary tract.
肾素 - 血管紧张素系统在体液、电解质平衡及血压稳态中的作用已为人所知甚久。近期进展表明，血管紧张素不仅在发育中的泌尿系统发挥着重要作用，在泌尿系统对损伤的反应中也起着关键作用。在本综述中，我们将概述这些特性。
我们总结了先天性肾脏和泌尿系统异常的临床处理方法，并报告了在基因工程小鼠中获得的新数据。此外，我们展示了突变小鼠观察结果与人类先天性异常之间的联系。
基因工程突变体明确表明，肾素 - 血管紧张素系统对正常肾脏和泌尿系统发育至关重要。与肾小球疾病一样，肾素 - 血管紧张素系统参与了泌尿系统疾病导致的进行性损伤。
虽然肾素 - 血管紧张素系统对血压调节很重要，但它也影响泌尿系统的胚胎发育，并调节特定疾病过程导致的肾损伤。血管紧张素及其阻断的重要性为先天性肾脏和泌尿系统异常儿童的早期治疗提供了一个令人兴奋的途径。
