Schonwald Alison, Lechner Erin
Children's Hospital, Boston, Massachusetts 02115, USA.
Curr Opin Pediatr. 2006 Apr;18(2):189-95. doi: 10.1097/01.mop.0000193302.70882.70.
Attention deficit/hyperactivity disorder continues to be a prevalent childhood behavioral disorder, with significant clinical and media interest. Providers must be current with research findings that impact the evolving understanding of this complex entity. This article summarizes recent progress in our view of attention deficit/hyperactivity disorder, with emphasis on controversies around diagnosis and treatment, and future management directions.
Literature about attention deficit/hyperactivity disorder in 2005 further enhanced our understanding of the genetic contribution to the expression of attention deficit/hyperactivity disorder, with exploration of sophisticated genetic models and their dynamic interaction with exposures and experiences. Previous literature focuses on conventional treatment; new developments in pharmacological/alternative options add to treatment choices, but have brought well publicized controversies. Furthermore, optimal management continues to gain evidence-based support.
Attention deficit/hyperactivity disorder is a subject of great interest to families, providers, researchers, and public forums. Scientific investigation supports a primary genetic contribution, but the relationship of molecular bases and environmental exposures appears intricate and complex. With increased awareness of this disorder, diagnostic dilemmas and medication side effects are more widely understood, topics particularly important to clinicians. Stimulant treatment remains the mainstay of intervention, but new delivery forms and nonstimulant options are potential therapies as well.
注意缺陷多动障碍仍是一种常见的儿童行为障碍,受到临床和媒体的广泛关注。医疗服务提供者必须紧跟研究进展,这些进展影响着我们对这个复杂病症不断演变的认识。本文总结了我们对注意缺陷多动障碍认识的最新进展,重点讨论了围绕诊断和治疗的争议以及未来的管理方向。
2005年有关注意缺陷多动障碍的文献进一步加深了我们对该病症遗传因素的理解,研究探索了复杂的遗传模型及其与暴露因素和经历的动态相互作用。以往文献主要关注传统治疗方法;药物治疗/替代疗法的新进展增加了治疗选择,但也引发了广为人知的争议。此外,最佳管理方法继续获得循证支持。
注意缺陷多动障碍是家庭、医疗服务提供者、研究人员和公共论坛极为关注的话题。科学研究支持其主要由遗传因素导致,但分子基础与环境暴露之间的关系似乎错综复杂。随着对该病症认识的提高,诊断难题和药物副作用得到了更广泛的理解,这些话题对临床医生尤为重要。兴奋剂治疗仍然是干预的主要手段,但新的给药形式和非兴奋剂选择也是潜在的治疗方法。