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注意缺陷/多动障碍:复杂性与争议

Attention deficit/hyperactivity disorder: complexities and controversies.

作者信息

Schonwald Alison, Lechner Erin

机构信息

Children's Hospital, Boston, Massachusetts 02115, USA.

出版信息

Curr Opin Pediatr. 2006 Apr;18(2):189-95. doi: 10.1097/01.mop.0000193302.70882.70.

DOI:10.1097/01.mop.0000193302.70882.70
PMID:16601502
Abstract

PURPOSE OF REVIEW

Attention deficit/hyperactivity disorder continues to be a prevalent childhood behavioral disorder, with significant clinical and media interest. Providers must be current with research findings that impact the evolving understanding of this complex entity. This article summarizes recent progress in our view of attention deficit/hyperactivity disorder, with emphasis on controversies around diagnosis and treatment, and future management directions.

RECENT FINDINGS

Literature about attention deficit/hyperactivity disorder in 2005 further enhanced our understanding of the genetic contribution to the expression of attention deficit/hyperactivity disorder, with exploration of sophisticated genetic models and their dynamic interaction with exposures and experiences. Previous literature focuses on conventional treatment; new developments in pharmacological/alternative options add to treatment choices, but have brought well publicized controversies. Furthermore, optimal management continues to gain evidence-based support.

SUMMARY

Attention deficit/hyperactivity disorder is a subject of great interest to families, providers, researchers, and public forums. Scientific investigation supports a primary genetic contribution, but the relationship of molecular bases and environmental exposures appears intricate and complex. With increased awareness of this disorder, diagnostic dilemmas and medication side effects are more widely understood, topics particularly important to clinicians. Stimulant treatment remains the mainstay of intervention, but new delivery forms and nonstimulant options are potential therapies as well.

摘要

综述目的

注意缺陷多动障碍仍是一种常见的儿童行为障碍,受到临床和媒体的广泛关注。医疗服务提供者必须紧跟研究进展,这些进展影响着我们对这个复杂病症不断演变的认识。本文总结了我们对注意缺陷多动障碍认识的最新进展,重点讨论了围绕诊断和治疗的争议以及未来的管理方向。

最新发现

2005年有关注意缺陷多动障碍的文献进一步加深了我们对该病症遗传因素的理解,研究探索了复杂的遗传模型及其与暴露因素和经历的动态相互作用。以往文献主要关注传统治疗方法;药物治疗/替代疗法的新进展增加了治疗选择,但也引发了广为人知的争议。此外,最佳管理方法继续获得循证支持。

总结

注意缺陷多动障碍是家庭、医疗服务提供者、研究人员和公共论坛极为关注的话题。科学研究支持其主要由遗传因素导致,但分子基础与环境暴露之间的关系似乎错综复杂。随着对该病症认识的提高,诊断难题和药物副作用得到了更广泛的理解,这些话题对临床医生尤为重要。兴奋剂治疗仍然是干预的主要手段,但新的给药形式和非兴奋剂选择也是潜在的治疗方法。

相似文献

1
Attention deficit/hyperactivity disorder: complexities and controversies.注意缺陷/多动障碍:复杂性与争议
Curr Opin Pediatr. 2006 Apr;18(2):189-95. doi: 10.1097/01.mop.0000193302.70882.70.
2
An update on central nervous system stimulant formulations in children and adolescents with attention-deficit/hyperactivity disorder.注意缺陷多动障碍儿童和青少年中枢神经系统兴奋剂制剂的最新情况
Ann Pharmacother. 2009 Jun;43(6):1084-95. doi: 10.1345/aph.1L523. Epub 2009 May 26.
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National estimates and factors associated with medication treatment for childhood attention-deficit/hyperactivity disorder.全国儿童注意力缺陷/多动障碍药物治疗的估计数据及相关因素。
Pediatrics. 2007 Feb;119 Suppl 1:S99-106. doi: 10.1542/peds.2006-2089O.
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Treatment of attention deficit hyperactivity disorder in adults.成人注意力缺陷多动障碍的治疗
Expert Rev Neurother. 2005 Jan;5(1):107-21. doi: 10.1586/14737175.5.1.107.
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Evolution of the treatment of attention-deficit/hyperactivity disorder in children: a review.儿童注意力缺陷多动障碍治疗的演变:综述
Clin Ther. 2008 May;30(5):942-57. doi: 10.1016/j.clinthera.2008.05.006.
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Pharmacotherapy for child and adolescent attention-deficit hyperactivity disorder.儿童及青少年注意力缺陷多动障碍的药物治疗
Pediatr Clin North Am. 2011 Feb;58(1):99-120, xi. doi: 10.1016/j.pcl.2010.10.009.
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Attention-deficit-hyperactivity disorder: an update.注意缺陷多动障碍:最新进展
Pharmacotherapy. 2009 Jun;29(6):656-79. doi: 10.1592/phco.29.6.656.
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Current strategies in the diagnosis and treatment of childhood attention-deficit/hyperactivity disorder.儿童注意力缺陷/多动障碍的诊断与治疗的当前策略
Am Fam Physician. 2009 Apr 15;79(8):657-65.
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Managing attention-deficit/hyperactivity disorder in primary care: a systematic analysis of roles and challenges.基层医疗中注意缺陷多动障碍的管理:角色与挑战的系统分析
Pediatrics. 2008 Jan;121(1):e65-72. doi: 10.1542/peds.2007-0383.
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New options in the pharmacological management of attention-deficit/hyperactivity disorder.注意缺陷多动障碍药物治疗的新选择。
Am J Manag Care. 2004 Jul;10(4 Suppl):S117-24.

引用本文的文献

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Nutrients. 2022 Feb 10;14(4):739. doi: 10.3390/nu14040739.
2
ADHD stimulant medication misuse and considerations for current prescribing practice: a literature review.注意缺陷多动障碍(ADHD)兴奋剂药物滥用及当前处方实践的注意事项:文献综述。
Ir J Med Sci. 2022 Feb;191(1):313-320. doi: 10.1007/s11845-020-02502-1. Epub 2021 Feb 9.
3
Why the Diagnosis of Attention Deficit Hyperactivity Disorder Matters.
为什么注意缺陷多动障碍的诊断很重要。
Front Psychiatry. 2015 Nov 26;6:168. doi: 10.3389/fpsyt.2015.00168. eCollection 2015.
4
Dopamine-modulated recurrent corticoefferent feedback in primary sensory cortex promotes detection of behaviorally relevant stimuli.多巴胺调制的初级感觉皮层中的皮质反馈反馈有助于检测与行为相关的刺激。
J Neurosci. 2014 Jan 22;34(4):1234-47. doi: 10.1523/JNEUROSCI.1990-13.2014.
5
Using environmental distractors in the diagnosis of ADHD.利用环境干扰物诊断 ADHD。
Front Hum Neurosci. 2013 Nov 22;7:805. doi: 10.3389/fnhum.2013.00805. eCollection 2013.
6
A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment.系统回顾和分析注意缺陷多动障碍的长期结局:治疗和非治疗的影响。
BMC Med. 2012 Sep 4;10:99. doi: 10.1186/1741-7015-10-99.