D'haeseleer Patrik
Microbial Systems Division, Biosciences Directorate, Lawrence Livermore National Laboratory, PO Box 808, L-448, Livermore, California 94551, USA.
Nat Biotechnol. 2006 Apr;24(4):423-5. doi: 10.1038/nbt0406-423.
Sequence motifs are becoming increasingly important in the analysis of gene regulation. How do we define sequence motifs, and why should we use sequence logos instead of consensus sequences to represent them? Do they have any relation with binding affinity? How do we search for new instances of a motif in this sea of DNA?
序列基序在基因调控分析中变得越来越重要。我们如何定义序列基序，以及为什么要用序列标识图而不是共有序列来表示它们？它们与结合亲和力有什么关系吗？我们如何在这片DNA海洋中搜索基序的新实例？
