Bartosová Lucie, Kuca Kamil, Kunesová Gabriela
Department of Toxicology, Faculty of Military Health Sciences, Hradec Králové, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):425-7. doi: 10.5507/bp.2005.073.
The present study was performed to assess and compare a therapeutic efficacy of obidoxime, HI-6, BI-6 and HS-6 administered in equimolar doses and combined with atropine in cyclosarin-poisoned mice and rats. It was demonstrated that all the therapeutic regimens tested, were able to decrease the cyclosarin-induced toxicity significantly - at least 1.5 times. Higher therapeutic ratios, almost three times, were achieved in rats in comparison with mice. The highest therapeutic ratio was achieved for therapeutic regimen consisting of HI-6 and atropine in both mice and rats. Obidoxime was the least effective oxime in the treatment of cyclosarin intoxication. The BI-6 oxime was significantly more efficacious than obidoxime (in both mice and rats) and HS-6 (in rats) but its effectiveness did not reach the efficacy of HI-6.
本研究旨在评估和比较等摩尔剂量的双复磷、HI-6、BI-6和HS-6与阿托品联合应用于环沙林中毒小鼠和大鼠的治疗效果。结果表明，所有测试的治疗方案均能显著降低环沙林诱导的毒性——至少降低1.5倍。与小鼠相比，大鼠的治疗比率更高，几乎是三倍。在小鼠和大鼠中，由HI-6和阿托品组成的治疗方案治疗比率最高。双复磷是治疗环沙林中毒效果最差的肟类药物。BI-6肟在治疗效果上显著优于双复磷（在小鼠和大鼠中）和HS-6（在大鼠中），但其效果未达到HI-6的疗效。
