新型α,α,α-三氟间甲苯基哒嗪酮衍生物的合成及其除草活性

Synthesis and herbicidal activity of novel alpha,alpha,alpha-trifluoro-m-tolyl pyridazinone derivatives.

作者信息

Xu Han, Zou Xiao-Mao, Zhu You-Quan, Liu Bin, Tao Han-Lin, Hu Xu-Hong, Song Hai-Bin, Hu Fang-Zhong, Wang Yong, Yang Hua-Zheng

机构信息

State Key Laboratory of Elemento-Organic Chemistry, Elemento-Organic Chemistry Institute, Nankai University, Tianjin 300071, China.

出版信息

Pest Manag Sci. 2006 Jun;62(6):522-30. doi: 10.1002/ps.1195.

DOI:10.1002/ps.1195

PMID:16602079

Abstract

A series of novel alpha,alpha,alpha-trifluoro-m-tolyl pyridazinone derivatives was synthesised. Herbicidal activities of the two intermediate compounds and 15 pyridazinone derivatives were evaluated through barnyardgrass and rape cup tests and Spirodela polyrrhiza (L.) Schleiden tests. Selected compounds were also evaluated under greenhouse conditions. Bleaching activities were observed at 10 microg ml(-1) and some compounds exhibited herbicidal activities at a rate of 300 g ha(-1). The relationship between crystal structures and herbicidal activities is discussed through a comparison of two compounds (5a and 5f).

摘要

合成了一系列新型的α,α,α-三氟间甲苯基哒嗪酮衍生物。通过稗草和油菜杯试验以及多花浮萍试验评估了两种中间化合物和15种哒嗪酮衍生物的除草活性。还在温室条件下对选定的化合物进行了评估。在10微克/毫升时观察到漂白活性，一些化合物在300克/公顷的用量下表现出除草活性。通过比较两种化合物（5a和5f）讨论了晶体结构与除草活性之间的关系。