新型 3-(取代苄氧基或苯氧基)-6-甲基-4-(3-三氟甲基苯基)哒嗪衍生物的合成与除草活性。
Synthesis and herbicidal activities of novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives.
机构信息
State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, National Engineering Research Center of Pesticide (Tianjin), Nankai University, Tianjin, China.
出版信息
Pest Manag Sci. 2012 Feb;68(2):276-84. doi: 10.1002/ps.2257. Epub 2011 Nov 10.
BACKGROUND
4-(3-Trifluoromethylphenyl)pyridazine represents a new series of compounds with bleaching and herbicidal activities.
RESULTS
A total of 43 novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives were synthesised, and their bleaching and herbicidal activities were evaluated through Spirodela polyrrhiza and greenhouse tests. Some compounds exhibited excellent herbicidal activities, even at a dose of 7.5 g ha(-1).
CONCLUSION
The results showed that a substituted phenoxy group at the 3-position of the pyridazine ring and the electron-withdrawing group at the para-position on the benzene ring were essential for high herbicidal activity.
背景
4-(3-三氟甲基苯基)哒嗪是一类具有漂白和除草活性的新型化合物。
结果
共合成了 43 种新型 3-（取代苄氧基或苯氧基）-6-甲基-4-（3-三氟甲基苯基）哒嗪衍生物，并通过水蕴草和温室试验评估了它们的漂白和除草活性。一些化合物表现出优异的除草活性，即使在 7.5 g ha(-1) 的剂量下也是如此。
结论
结果表明，哒嗪环 3 位取代的苯氧基和苯环对位的吸电子基团对于高除草活性是必不可少的。
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