Ma Xining, Sun Ping, Wang Jiaxin, Huang Xinyu, Wu Jian
State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Mol Divers. 2024 Dec 26. doi: 10.1007/s11030-024-11083-5.
Pyridazine and pyridazinone belong to the same group of six-membered heterocyclic compounds, and both structurally feature two adjacent nitrogen atoms. Pyridazine and pyridazinone derivatives are frequently used as core structures in the development of new green agrochemicals due to their high activity and environmental friendliness, attracting significant attention from researchers in recent years. Over the past 20 years, significant developments have occurred in the field of pyridazine and pyridazinone derivatives, which exhibit insecticidal, fungicidal, herbicidal, antiviral, and plant growth regulating activities. Hence, summarizing the process of creating novel molecules with pyridazine and pyridazinone structures through design concepts, understanding structure-activity relationships, and mechanisms of action is an important undertaking. This review aims to provide a comprehensive overview of these advancements, shedding light on the discovery and mechanism of action of novel pesticides in the pyridazine and pyridazinone categories.
哒嗪和哒嗪酮属于同组六元杂环化合物，二者在结构上均具有两个相邻的氮原子。哒嗪和哒嗪酮衍生物因其高活性和环境友好性，常被用作新型绿色农用化学品开发的核心结构，近年来受到研究人员的广泛关注。在过去20年里，哒嗪和哒嗪酮衍生物领域取得了重大进展，这些衍生物具有杀虫、杀菌、除草、抗病毒和调节植物生长的活性。因此，通过设计理念总结利用哒嗪和哒嗪酮结构创造新型分子的过程，理解构效关系和作用机制是一项重要工作。本综述旨在全面概述这些进展，阐明哒嗪和哒嗪酮类新型农药的发现及作用机制。
