de Vasconcelos C L, Bezerril P M, dos Santos D E S, Dantas T N C, Pereira M R, Fonseca J L C
Departamento de Química, Universidade Federal do Rio Grande do Norte, Campus Universitario, Lagoa Nova, RN 59078-970, Brazil.
Biomacromolecules. 2006 Apr;7(4):1245-52. doi: 10.1021/bm050963w.
Chitosan/poly(methacrylic acid) complexes, CS/PMAA, were prepared via dropwise addition of a solution of PMAA to a solution of chitosan in acetic acid 2 wt %. The increase in molecular weight of PMAA inhibited the formation of insoluble complexes, while the increase in ionic strength first favored the formation of the complex followed by inhibiting it at higher concentrations. These observations were related to a description of polyelectrolyte complexation that was strongly dependent on macromolecular dimensions, both in terms of molecular weight and of coil expansion/contraction driven by polyelectrolyte effect.
通过将聚甲基丙烯酸（PMAA）溶液逐滴加入到2 wt%乙酸中的壳聚糖溶液中，制备了壳聚糖/聚甲基丙烯酸（CS/PMAA）复合物。聚甲基丙烯酸分子量的增加抑制了不溶性复合物的形成，而离子强度的增加首先有利于复合物的形成，随后在较高浓度下又抑制了复合物的形成。这些观察结果与聚电解质络合的描述有关，聚电解质络合在很大程度上取决于大分子尺寸，包括分子量以及由聚电解质效应驱动的线圈膨胀/收缩。
