Lugović Liborija, Cupić Hrvoje, Lipozencić Jasna, Jakić-Razumović Jasminka
University Department of Dermatology and Venereology, Sestre milosrdnice University Hospital, Vinogradska cesta 29, HR-10000 Zagreb, Croatia.
Acta Dermatovenerol Croat. 2006;14(1):2-7.
Adhesion molecules may play an important role in the homing of T-cell subsets into allergen-exposed skin of atopic individuals. The aim of this pilot study was to examine the expression of adhesion molecules in atopic dermatitis (AD) skin lesions. Biopsies were taken at acute skin lesions from 10 AD patients and 5 healthy controls, and were studied by immunohistocytochemistry for the expression of E-selectin, L-selectin, ICAM-1 and ICAM-3 on cells in the epidermis and dermis. Study results revealed all AD patients to express ICAM-1 (10/10) and ICAM-3 (10/10) in the dermis, and most of them to express E-selectin (9/10) and L-selectin (6/10) in the dermis, without expression of E- and L-selectins in the epidermis. Our results revealed a high expression of adhesion molecules, especially ICAM-1 and ICAM-3, in the skin lesions of AD patients, which may play an important role in the pathogenesis of AD, and these preliminary results may be of clinical relevance for the treatment of AD.
黏附分子可能在T细胞亚群归巢至特应性个体暴露于变应原的皮肤中发挥重要作用。本初步研究的目的是检测特应性皮炎（AD）皮肤病变中黏附分子的表达情况。对10例AD患者和5例健康对照的急性皮肤病变进行活检，采用免疫组织化学方法研究表皮和真皮中细胞上E选择素、L选择素、细胞间黏附分子-1（ICAM-1）和细胞间黏附分子-3（ICAM-3）的表达。研究结果显示，所有AD患者的真皮中均表达ICAM-1（10/10）和ICAM-3（10/10），大多数患者的真皮中表达E选择素（9/10）和L选择素（6/10），而表皮中未表达E选择素和L选择素。我们的结果显示，AD患者皮肤病变中黏附分子，尤其是ICAM-1和ICAM-3，表达较高，这可能在AD的发病机制中起重要作用，这些初步结果可能对AD的治疗具有临床意义。
