Rudra Carole B, Qiu Chunfang, David Robert M, Bralley J Alexander, Walsh Scott W, Williams Michelle A
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA.
Clin Biochem. 2006 Jul;39(7):722-6. doi: 10.1016/j.clinbiochem.2006.02.009. Epub 2006 Apr 5.
Preeclampsia is associated with elevated plasma malondialdehyde concentration, but prospective data are scarce. We examined the relation between early-pregnancy plasma malondialdehyde and subsequent preeclampsia risk.
In a nested case-control analysis, we measured malondialdehyde concentrations in 22 women who developed preeclampsia and 711 who remained normotensive during pregnancy. We calculated adjusted odds ratios (OR) and 95% confidence intervals (CI). We repeated analyses after adjustment for early-pregnancy plasma lipid concentrations, which are related to preeclampsia risk and lipid peroxidation measures.
After adjustment for confounders, preeclampsia risk increased across tertiles of malondialdehyde concentration (trend P = 0.04). Further adjustment for triglyceride concentration slightly strengthened the association. Middle- and high-tertile malondialdehyde ORs were 3.2 (CI 0.8-12.2) and 4.2 (1.1-16.0) versus low-tertile exposure.
Early-pregnancy plasma malondialdehyde concentration is positively associated with subsequent preeclampsia risk independent of plasma lipid concentrations. These results support lipid peroxidation as an etiologic component of preeclampsia.
子痫前期与血浆丙二醛浓度升高有关，但前瞻性数据较少。我们研究了孕早期血浆丙二醛与随后发生子痫前期风险之间的关系。
在一项巢式病例对照分析中，我们测量了22例发生子痫前期的女性和711例孕期血压正常女性的丙二醛浓度。我们计算了调整后的比值比（OR）和95%置信区间（CI）。在对与子痫前期风险和脂质过氧化指标相关的孕早期血浆脂质浓度进行调整后，我们重复了分析。
在对混杂因素进行调整后，子痫前期风险随着丙二醛浓度三分位数的升高而增加（趋势P = 0.04）。对甘油三酯浓度进行进一步调整后，这种关联略有增强。与低三分位数暴露相比，中、高三分位数丙二醛的OR分别为3.2（CI 0.8 - 12.2）和4.2（1.1 - 16.0）。
孕早期血浆丙二醛浓度与随后发生子痫前期的风险呈正相关，且独立于血浆脂质浓度。这些结果支持脂质过氧化是子痫前期的一个病因学因素。
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