Department of Medical Imaging and Therapeutic Sciences, College of Allied Health Professions, University of Nebraska Medical Center (UNMC), Omaha, USA.
Department of Cellular and Integrative Physiology, UNMC, Omaha, USA.
Pregnancy Hypertens. 2019 Oct;18:99-102. doi: 10.1016/j.preghy.2019.09.014. Epub 2019 Oct 3.
Preeclampsia (PE), one of the most serious complications of pregnancy, is characterized by endothelial dysfunction and hypertension. The pathophysiology of the disease is still unknown; however, evidence suggests that placental and maternal oxidative stress promote the disease process. Several studies have assessed levels of oxidative stress during pregnancy, but after diagnosis of PE. However, few studies have examined oxidative stress before PE diagnosis. Thus, the present work was aimed to gain further insight into the role of oxidative stress prior to diagnosis of PE (i.e. 12-20 weeks of gestation) and to further understand and predict PE incidence.
Blood levels of superoxide (O) and erythrocyte antioxidants such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and oxidized glutathione (GSSG) levels were measured in 23 preeclamptic pregnant women and 91 women with normal pregnancies. We further used logistic regression of O and each antioxidant level as the main predictor variable for PE risk.
CAT activity, GSH, and Total glutathione (TGSH) were significantly lower with All PE pregnant groups, whereas O levels were modestly, but significantly, higher in women with mild PE. Logistic regression analysis suggests increased CAT activity in pregnant women is associated with a decreased odds of being preeclamptic.
CAT is the only antioxidant as shown in our study to be related to the severity of the disease and may be a promising predictor for PE. Further studies are warranted to investigate the use of CAT as a novel therapeutic for PE.
子痫前期（PE）是妊娠最严重的并发症之一，其特征为血管内皮功能障碍和高血压。该疾病的病理生理学仍不清楚；然而，有证据表明胎盘和母体的氧化应激会促进疾病的发生。一些研究已经评估了妊娠期间的氧化应激水平，但都是在 PE 诊断之后。然而，很少有研究在 PE 诊断之前检测氧化应激。因此，本研究旨在深入了解 PE 诊断前（即妊娠 12-20 周）氧化应激的作用，并进一步了解和预测 PE 的发生。
在 23 例子痫前期孕妇和 91 例正常妊娠妇女中测量了超氧阴离子（O）和红细胞抗氧化剂（如超氧化物歧化酶[SOD]、过氧化氢酶[CAT]、还原型谷胱甘肽[GSH]和氧化型谷胱甘肽[GSSG]）的血液水平。我们进一步使用 O 和每种抗氧化剂水平的逻辑回归作为主要预测变量，对 PE 风险进行分析。
CAT 活性、GSH 和总谷胱甘肽（TGSH）在所有 PE 孕妇组中均显著降低，而轻度 PE 组妇女的 O 水平略有但显著升高。逻辑回归分析表明，CAT 活性的增加与子痫前期的发生几率降低有关。
在我们的研究中，CAT 是唯一与疾病严重程度相关的抗氧化剂，可能是预测 PE 的一个有前途的指标。需要进一步的研究来探讨 CAT 作为一种新型治疗方法用于治疗 PE 的可能性。
