Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington, USA.
Clin Biochem. 2011 Jul;44(10-11):804-8. doi: 10.1016/j.clinbiochem.2011.04.023. Epub 2011 May 13.
To examine the association of maternal early pregnancy oxidative stress with risk of gestational diabetes mellitus (GDM).
A pilot prospective, nested case-control study was conducted. Study participants were recruited before 20weeks gestation. Maternal urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of systemic oxidative DNA damage and repair, was measured using competitive immunoassays. Logistic regression was used to calculate odds ratio (OR) and 95% confidence intervals (95%CI).
Elevations in early pregnancy urinary 8-OHdG concentrations were associated with increased GDM risk. After adjusting for confounders, the OR for extreme quartiles (≥8.01 vs. <4.23ng/mg creatinine) of 8-OHdG was 3.79 (95%CI 1.03-14.00). The risk for GDM was highest for overweight women with urine 8-OHdG concentrations ≥8.01ng/mg creatinine (OR=5.36, 95%CI 1.33-21.55) when compared with lean women who had 8-OHdG concentrations <8.01ng/mg creatinine.
Elevated urine 8-OHdG concentrations in early pregnancy appear to be associated with increased GDM risk.
探讨母体早孕氧化应激与妊娠期糖尿病（GDM）风险的关系。
进行了一项前瞻性、巢式病例对照研究。研究参与者在 20 周妊娠前招募。使用竞争性免疫测定法测量母体尿 8-羟基脱氧鸟苷（8-OHdG），这是一种系统性氧化 DNA 损伤和修复的生物标志物。使用逻辑回归计算比值比（OR）和 95%置信区间（95%CI）。
早孕尿 8-OHdG 浓度升高与 GDM 风险增加相关。在调整混杂因素后，8-OHdG 极端四分位数（≥8.01 与 <4.23ng/mg 肌酐）的 OR 为 3.79（95%CI 1.03-14.00）。与尿 8-OHdG 浓度 <8.01ng/mg 肌酐的瘦型女性相比，超重女性的尿液 8-OHdG 浓度≥8.01ng/mg 肌酐时 GDM 的风险最高（OR=5.36，95%CI 1.33-21.55）。
早孕尿 8-OHdG 浓度升高似乎与 GDM 风险增加有关。
