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T细胞活化中的免疫突触。

Immune synapses in T-cell activation.

作者信息

Cemerski Saso, Shaw Andrey

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

出版信息

Curr Opin Immunol. 2006 Jun;18(3):298-304. doi: 10.1016/j.coi.2006.03.011. Epub 2006 Apr 17.

Abstract

The contact site between T cells and antigen-presenting cells or T cells and their targets--the immunological synapse--is a highly specialized structure potentially involved in T-cell activation and function. Although many insights have been obtained since the initial description of the immune synapse, recent advances have provided us with a better understanding of mechanisms involved in synapse formation and in the diversity of synapse morphologies. New potential roles for the synapse such as in polarized cytokine secretion or in adaptive control of T-cell activation have been proposed.

摘要

T细胞与抗原呈递细胞之间或T细胞与其靶细胞之间的接触部位——免疫突触——是一种高度特化的结构,可能参与T细胞的激活和功能。尽管自免疫突触首次被描述以来已获得了许多见解,但最近的进展使我们对突触形成机制和突触形态多样性有了更好的理解。有人提出了突触的新潜在作用,如在极化细胞因子分泌或T细胞激活的适应性控制方面。

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