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脂质管理可降低糖尿病和糖尿病前期患者的心血管并发症风险。

Lipid management reduces cardiovascular complications in individuals with diabetes and prediabetes.

作者信息

Gosavi Aparna, Flaker Gregory, Gardner David

机构信息

Department of Internal Medicine, University of Missouri, Columbia, Columbia, MO 65212, USA.

出版信息

Prev Cardiol. 2006 Spring;9(2):102-7; quiz 108-9. doi: 10.1111/j.1520-037x.2000.4071.x.

Abstract

Patients with type 2 diabetes are known to have an elevated risk of cardiovascular morbidity and mortality. Prior to the development of hyperglycemia and type 2 diabetes, individuals undergo a prolonged prediabetic phase involving hyperglycemia and insulin resistance. This has been associated with increased cardiovascular risk and is considered a cardiovascular risk equivalent. It is well known that dyslipidemia is an important contributor to the development of coronary artery disease. Treating diabetes with lipid-lowering agents reduces patients' cardiovascular risk. Preliminary studies have shown that similar benefits are seen even in persons with prediabetes. Hence, lipid-lowering agents should be considered not only in patients with type 2 diabetes, but also in individuals with prediabetes and with elevated lipid levels.

摘要

众所周知,2型糖尿病患者发生心血管疾病和死亡的风险会升高。在高血糖和2型糖尿病发生之前,个体要经历一个漫长的糖尿病前期阶段,包括高血糖和胰岛素抵抗。这与心血管风险增加有关,并被视为心血管风险等同情况。众所周知,血脂异常是冠状动脉疾病发展的一个重要因素。用降脂药物治疗糖尿病可降低患者的心血管风险。初步研究表明,即使在糖尿病前期患者中也能看到类似的益处。因此,不仅2型糖尿病患者,而且糖尿病前期且血脂水平升高的个体都应考虑使用降脂药物。

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