Gosavi Aparna, Flaker Gregory, Gardner David
Department of Internal Medicine, University of Missouri, Columbia, Columbia, MO 65212, USA.
Prev Cardiol. 2006 Spring;9(2):102-7; quiz 108-9. doi: 10.1111/j.1520-037x.2000.4071.x.
Patients with type 2 diabetes are known to have an elevated risk of cardiovascular morbidity and mortality. Prior to the development of hyperglycemia and type 2 diabetes, individuals undergo a prolonged prediabetic phase involving hyperglycemia and insulin resistance. This has been associated with increased cardiovascular risk and is considered a cardiovascular risk equivalent. It is well known that dyslipidemia is an important contributor to the development of coronary artery disease. Treating diabetes with lipid-lowering agents reduces patients' cardiovascular risk. Preliminary studies have shown that similar benefits are seen even in persons with prediabetes. Hence, lipid-lowering agents should be considered not only in patients with type 2 diabetes, but also in individuals with prediabetes and with elevated lipid levels.
众所周知,2型糖尿病患者发生心血管疾病和死亡的风险会升高。在高血糖和2型糖尿病发生之前,个体要经历一个漫长的糖尿病前期阶段,包括高血糖和胰岛素抵抗。这与心血管风险增加有关,并被视为心血管风险等同情况。众所周知,血脂异常是冠状动脉疾病发展的一个重要因素。用降脂药物治疗糖尿病可降低患者的心血管风险。初步研究表明,即使在糖尿病前期患者中也能看到类似的益处。因此,不仅2型糖尿病患者,而且糖尿病前期且血脂水平升高的个体都应考虑使用降脂药物。