核受体共调节因子在靶基因表达调控中的序列性和持续性
Sequentiality and processivity of nuclear receptor coregulators in regulation of target gene expression.
作者信息
O'Malley Bert W
机构信息
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Nucl Recept Signal. 2003;1:e010. doi: 10.1621/nrs.01010. Epub 2003 Oct 25.
Abstract
A series of data has accumulated over the past five years that raises questions about our current understanding of the transcriptional process and its regulation. Following the discovery of coactivators for nuclear receptors (NRs), a large number of these molecules have been reported in the literature. This perspective will summarize some opinions on the significance of this large number of factors.
摘要
在过去五年里积累了一系列数据，这些数据对我们目前对转录过程及其调控的理解提出了质疑。继核受体（NRs）共激活因子被发现之后，文献中已报道了大量此类分子。本观点将总结关于如此众多因子的重要性的一些看法。
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