重复鞘内注射曲安奈德可减轻复发缓解型多发性硬化症患者急性发作的疼痛性感觉异常。

Repeat intrathecal triamcinolone acetonide application reduces acute occurring painful dysesthesia in patients with relapsing remitting multiple sclerosis.

作者信息

Hellwig Kerstin, Lukas Carsten, Brune Niels, Schimrigk Sebastian, Przuntek Horst, Müller Thomas

机构信息

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany.

出版信息

ScientificWorldJournal. 2006 Apr 6;6:460-5. doi: 10.1100/tsw.2006.86.

DOI:10.1100/tsw.2006.86

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917289/

Abstract

We describe four patients with relapsing remitting multiple sclerosis (RRMS) who experienced a relapse with acute onset of painful sensations. Pain sensations disappeared in two of them and markedly reduced in the other ones after repeat application of intrathecal triamcinolone acetonide (TCA) following a prior unsuccessful treatment with intravenous steroids. TCA administration was well tolerated and no serious side effects occurred. Repeated intrathecal TCA injection may provide a substantial benefit in RRMS patients with acute onset of pain due to an inflammatory lesion within the spinal cord.

摘要

我们描述了4例复发缓解型多发性硬化症（RRMS）患者，他们经历了伴有急性疼痛发作的病情复发。其中2例患者的疼痛感消失，另外几例在先前静脉注射类固醇治疗失败后，再次鞘内注射曲安奈德（TCA）后疼痛感明显减轻。TCA给药耐受性良好，未出现严重副作用。对于因脊髓内炎性病变导致急性疼痛发作的RRMS患者，重复鞘内注射TCA可能会带来显著益处。

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