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树突电压门控通道的记录、分析及功能

Recording, analysis, and function of dendritic voltage-gated channels.

作者信息

Gurkiewicz Meron, Korngreen Alon

机构信息

The Mina and Everand Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, 52900, Israel.

出版信息

Pflugers Arch. 2006 Dec;453(3):283-92. doi: 10.1007/s00424-006-0076-3. Epub 2006 Apr 8.

DOI:10.1007/s00424-006-0076-3
PMID:16604366
Abstract

Ever since the publication of the Hamill et al. [Hamill et al., Pflügers Arch, 391:85-100, 1981] paper and the following increase in popularity of acute brain slice preparations, there has been a large increase in the volume of publications investigating voltage-gated channels in the central nervous system using the patch-clamp technique. In the preceding decade, investigations of voltage-gated channels have moved out of the somatic region into dendrites providing much needed information about dendritic voltage-gated channels. In this study, we review some aspects related to the investigation of voltage-gated ion channels in dendrites: recording, analysis, and function.

摘要

自从哈米尔等人[哈米尔等人,《 Pflügers 文献》,391:85 - 100,1981]的论文发表以及随后急性脑片制备方法的普及以来,使用膜片钳技术研究中枢神经系统电压门控通道的出版物数量大幅增加。在之前的十年里,对电压门控通道的研究已从胞体区域扩展到树突,提供了关于树突电压门控通道急需的信息。在本研究中,我们回顾了与树突中电压门控离子通道研究相关的一些方面:记录、分析和功能。

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Optimization by simulated annealing.模拟退火优化。
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Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons.海马CA1锥体神经元树突中组成型激活的G蛋白门控内向整流钾通道。
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