Kuriyama K, Hirouchi M
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Nihon Yakurigaku Zasshi. 1991 Sep;98(3):161-8. doi: 10.1254/fpj.98.3_161.
GABA receptors are classified into two receptor subtypes: GABAA and GABAB receptors. The GABAA receptor, one of the ionotropic type receptors, is formed by various subunits (alpha, beta, gamma and delta subunits) and constitutes the GABA-gated Cl- channel. The different combinations of these subunits are known to produce functionally heterogeneous GABAA receptors both pharmacologically and physiologically. On the other hand, GABAB receptor is known to be metabotropic type which is negatively coupled with adenylate cyclase and inositol phosphate turnover systems via inhibitory GTP binding protein.
γ-氨基丁酸（GABA）受体可分为两种受体亚型：GABAA和GABAB受体。GABAA受体是促离子型受体之一，由多种亚基（α、β、γ和δ亚基）组成，构成GABA门控氯离子通道。已知这些亚基的不同组合在药理学和生理学上产生功能异质性的GABAA受体。另一方面，GABAB受体是促代谢型受体，通过抑制性GTP结合蛋白与腺苷酸环化酶和肌醇磷酸周转系统负性偶联。
