Hirouchi M, Kuriyama K
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Nihon Yakurigaku Zasshi. 1994 Sep;104(3):199-206. doi: 10.1254/fpj.104.199.
The receptor for gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian brain, has been classified into GABAA and GABAB subtypes. The GABAA receptor forms a Cl- channel and is consisted of several subunits. These subunits in the brain are known to be multiple and heterogeneous in their molecular structure. Therefore, it is suggested that these multiple GABAA receptors generate various inhibitory functions in the brain. In contrast, the GABAB receptor is known to be one of the metabotropic type of receptors which generate slow inhibitory postsynaptic potentials and functionally couple with Gi/Go types of GTP-binding proteins. The GABAB receptor in the brain has been purified to homogeneity using immunoaffinity purification procedures and found to be an 80-kDa protein. The possible existence of multiplicity in the cerebral GABAB receptor has also been suggested.
γ-氨基丁酸（GABA）是哺乳动物大脑中的一种主要抑制性神经递质，其受体已被分为GABAA和GABAB亚型。GABAA受体形成一个氯离子通道，由几个亚基组成。已知大脑中的这些亚基在分子结构上具有多样性和异质性。因此，有人提出这些多种GABAA受体在大脑中产生各种抑制功能。相比之下，GABAB受体是促代谢型受体之一，可产生缓慢的抑制性突触后电位，并在功能上与Gi/Go型GTP结合蛋白偶联。大脑中的GABAB受体已通过免疫亲和纯化程序纯化至同质，发现是一种80 kDa的蛋白质。也有人提出大脑GABAB受体可能存在多样性。
