Wang Qing-hua, Chen Wei-zhen, Tan Jian-ming
Department of Urology, Fuzhou General Hospital, Nanjing Command of PLA, Fuzhou, Fujian, 350025 P.R.China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Apr;23(2):240-1.
To investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population.
Six hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations.
Fourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1*9, 12, 15, 4, 8 respectively.
The HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations.
研究福建汉族人群中HLA - DRB1等位基因多态性。
采用寡核苷酸微阵列技术对620例来自福建汉族无关个体样本进行基因分型。计算HLA - DRB1的等位基因频率，并与其他人群进行比较。
检测到福建汉族人群14种HLA - DRB1等位基因。基因频率由高到低依次为HLA - DRB1*9、12、15、4、8。
福建汉族人群的HLA - DRB1分布与中国南方汉族人群有一些遗传特征相同，但与中国北方人群不同。
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