Li Dan, Liu Hai-yan, Xi Bin, Yu Yan
HLA Laboratory, People's Hospital and Institute of Hematology, Beijing University, Beijing, 100044 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Aug;20(4):325-7.
To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China.
This study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique.
Fourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.
The results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.
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