内蒙古鄂温克族 HLA - DRB1 基因多态性研究
[HLA-DRB1 polymorphism in the Ewenki Ethnic of Inner Mongolian].
作者信息
Hai Rong, Bi Li-fu, Su Xiu-lan
机构信息
Clinical Medical Research Center, Inner Mongolian Medical College, Huhehhte, Inner Mongolian 010050, P.R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Feb;23(1):95-6.
OBJECTIVE
To study the HLA-DRB1 genetic polymorphism in the Ewenki of Inner mongolia.
METHODS
HLA-DRB1 allele polymorphisms in 84 normal Ewenki were determined by PCR with sequencing based typing (SBT).
RESULTS
Twenty-five HLA-DRB1 alleles were observed. The allele frequency of HLA-DRB103011(14.88%) is the highest; the allele frequencies of HLA -DRB109012 (13.69%), DRB107011(8.92%), DRB104011(9.52%) and DRB1*12011(8.33%) are lower.
CONCLUSION
The distribution of HLA-DRB1 alleles frequencies in normal Ewenki from Inner Mongolia exhibits a unique profile, which is of important reference value for studies on anthropology and related illnesses in Ewenki population.
目的
研究内蒙古鄂温克族人群中HLA-DRB1基因多态性。
方法
采用聚合酶链反应-测序分型（SBT）技术检测84名正常鄂温克族个体的HLA-DRB1等位基因多态性。
结果
共检测到25种HLA-DRB1等位基因。其中，HLA-DRB103011等位基因频率最高（14.88%）；HLA -DRB109012（13.69%）、DRB107011（8.92%）、DRB104011（9.52%）和DRB1*12011（8.33%）等位基因频率较低。
结论
内蒙古正常鄂温克族人群HLA-DRB1等位基因频率分布具有独特特征，对鄂温克族人群的人类学及相关疾病研究具有重要参考价值。
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