Revaz Sylvie, Dudler Jean
Service de rhumatologie, médecine physique et réhabilitation, CHUV, 1011 Lausanne.
Rev Med Suisse. 2006 Mar 15;2(57):721-2, 725-6.
Reactive arthritis is a disease closely related to the presence of the HLA-B27 antigen and characterized by sterile joint inflammation secondary to infection. Arthritis is only one of the clinical manifestations of this systemic disease. Its diagnosis rests on history, clinical examination and various serologies. The prognosis is generally good, but recurrences are frequent, in particular in HLA-B27 positive patients. Treatment is mainly symptomatic, and antibiotics should be prescribed only in the event of an active infection. A 3 months course of antibiotics could be beneficial on the long-term evolution in HLA-B27 positive patients, but this practice deserves to be confirmed by additional randomized controlled studies.
反应性关节炎是一种与HLA - B27抗原的存在密切相关的疾病,其特征为继发于感染后的无菌性关节炎症。关节炎只是这种全身性疾病的临床表现之一。其诊断基于病史、临床检查及各种血清学检查。总体预后良好,但复发频繁,尤其是在HLA - B27阳性患者中。治疗主要是对症治疗,仅在有活动性感染时才应使用抗生素。对于HLA - B27阳性患者,3个月疗程的抗生素可能对其长期病情发展有益,但这种做法值得更多随机对照研究予以证实。