反应性关节炎

Reactive arthritis.

作者信息

Petersel Danielle Lauren, Sigal Leonard H

机构信息

Division of Rheumatology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, MEB484, PO Box 19, New Brunswick, NJ 08903-0019, USA.

出版信息

Infect Dis Clin North Am. 2005 Dec;19(4):863-83. doi: 10.1016/j.idc.2005.07.001.

DOI:10.1016/j.idc.2005.07.001

PMID:16297737

Abstract

ReA consists of sterile axial or peripheral articular inflammation,enthesitis, and extra-articular manifestations. Most patients are HLA-B27 positive, although determining the B27 status of an individual patient is irrelevant. Exposure to specific bacterial antigens is usually the inciting factor. Diagnosis usually can be made by clinical examination and history. The current standard therapy is NSAIDs and physiotherapy, but molecular biologic treatment may ultimately become the mainstay in recalcitrant and severe ReA.

摘要

反应性关节炎由无菌性轴性或外周关节炎症、肌腱端炎和关节外表现组成。大多数患者 HLA - B27 呈阳性，不过确定个体患者的 B27 状态并无关联。接触特定细菌抗原通常是诱发因素。诊断通常可通过临床检查和病史做出。目前的标准治疗是使用非甾体抗炎药和物理治疗，但分子生物学治疗最终可能会成为难治性和重度反应性关节炎的主要治疗方法。