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5-氟尿嘧啶对外分泌腺的作用。III. 大鼠 Brunner 腺的精细结构

Effects of 5-fluorouracil on exocrine glands. III. Fine structure of Brunner's glands of rats.

作者信息

Anand C, Han S S

出版信息

J Anat. 1975 Feb;119(Pt 1):1-17.

PMID:166061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1231611/
Abstract

Effects of a pyrimidine analogue, 5-fluorouracil (Fur), have been studied by electron microscopy and by electron microscopic cytochemical techniques. Previous studies have demonstrated that rats show serious gastrointestinal disturbances 5 days after 3 daily injections of FUR (50 mg/kg). The present investigation demonstrates that Brunner's glands under the same conditions suffer certain cytological changes involving the Golgi apparatus, where a notable reduction in the number of Golgi stacks is observed. The vacuolar components in the Golgi complex appear empty. Cytochemical localizations of uridine diphosphatase and thiamine pyrophosphatase activities, however, are normal. The reaction products are localized in the distal two or three lamellae of the Golgi stack and within the secretory granules nearby. In addition reaction products are present along the apical plasma membrane on the luminal side, suggesting a possible movement of these membranes from the Golgi stack, via secretory granules, to the apical plasma membrane.

摘要

已通过电子显微镜和电子显微镜细胞化学技术研究了嘧啶类似物5-氟尿嘧啶（Fur）的作用。先前的研究表明，大鼠在每日注射3次FUR（50mg/kg）5天后会出现严重的胃肠道紊乱。本研究表明，在相同条件下，布伦纳腺会发生某些涉及高尔基体的细胞学变化，观察到高尔基体堆叠的数量明显减少。高尔基复合体中的液泡成分显得空洞。然而，尿苷二磷酸酶和硫胺素焦磷酸酶活性的细胞化学定位是正常的。反应产物定位于高尔基体堆叠的远端两三层片层以及附近的分泌颗粒内。此外，反应产物沿管腔侧的顶端质膜存在，表明这些膜可能从高尔基体堆叠通过分泌颗粒移动到顶端质膜。

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本文引用的文献

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Nucleic Acid Metabolism in Peanut Cotyledons.花生子叶中的核酸代谢
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The role of 5-fluorouracil in malignant disease.5-氟尿嘧啶在恶性疾病中的作用。
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Massive incorporation of 5-fluorouracil into a bacterial ribonucleic acid.5-氟尿嘧啶大量掺入细菌核糖核酸中。
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THE HISTOCHEMISTRY AND ELECTRONMICROSCOPY OF BRUNNER'S GLANDS IN THE GUINEA-PIG.豚鼠布鲁纳氏腺的组织化学与电子显微镜观察
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THE MECHANISM OF ACTION OF PURINE AND PYRIMIDINE ANALOGS IN MICROORGANISMS.嘌呤和嘧啶类似物在微生物中的作用机制
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The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.在电子显微镜检查中，将高pH值的柠檬酸铅用作电子不透明染色剂。
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Junctional complexes in various epithelia.各种上皮组织中的连接复合体。
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