Ribas-Fitó Núria, Gladen Beth C, Brock John W, Klebanoff Mark A, Longnecker Matthew P
Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA.
Int J Epidemiol. 2006 Aug;35(4):853-8. doi: 10.1093/ije/dyl067. Epub 2006 Apr 10.
To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design Prospective cohort study. Participants 1,712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy. Setting Multicenter US Collaborative Perinatal Project (CPP).
The highest prenatal concentrations of p,p'-DDE (>or=60 microg/l), as compared with the lowest (<15 microg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = -0.72 cm (0.37), n = 1,540], 4 years [-1.14 cm (0.56), n = 1,289], and 7 years [-2.19 (0.46), n = 1,371]. Among subjects in lower categories of exposure no association was observed.
The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected.
研究孕期1,1-二氯-2,2-双（对氯苯基）乙烯（p,p'-DDE，杀虫剂滴滴涕的一种代谢产物）暴露与儿童出生后7年内生长发育之间的关系。设计前瞻性队列研究。参与者为1959年至1966年间出生的1712名儿童，其母亲孕期血清样本中p,p'-DDE浓度已测定。研究地点为美国多中心围产期协作项目（CPP）。
与最低浓度组（<15微克/升）相比，孕期p,p'-DDE最高浓度组（≥60微克/升）与1岁时身高降低相关[校正系数（标准误）=-0.72厘米（0.37），n = 1540]，4岁时[-1.14厘米（0.56），n = 1289]，以及7岁时[-2.19（0.46），n = 1371]。在较低暴露水平组的受试者中未观察到相关性。
研究结果表明，孕期高暴露于p,p'-DDE会降低儿童身高。生长发育受损可能是毒性的一个总体指标，提示特定器官系统（如内分泌系统）可能受到影响。
