Department-Centre of Monitoring and Analyses of Population Health, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.
Environ Health. 2010 Sep 6;9:56. doi: 10.1186/1476-069X-9-56.
Epidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies.
Blood samples were collected from interviewed pregnant women in Greenland (572), Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas chromatography-mass spectrometry. Data on birth weight, gestational age and preterm birth were obtained for 1322 singleton live births. We examined the association between natural log-transformed serum POPs concentration and birth weight and gestational age using multiple linear regression and the association with prematurity using logistic regression controlling for potential confounding factors.
The median serum concentrations of CB-153 and p,p'-DDE were for Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 concentration by one unit on the log scale in Inuit mothers serum was associated with significant decrease in infant birth weight of -59 g and gestational age by -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in p,p'-DDE concentration by one unit on the log scale was associated with a statistically significant decrease in infant birth weight of -39.4 g and -104.3 g and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight (-30.5 g) was not significant, however a shortening of gestational age of -0.2 week per increase in p,p'-DDE concentration by one unit on the log scale was of the borderline significance. There was no significant association between CB-153 and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the odds ratio was above 1.
In utero exposure to POPs may reduce birth weight and gestational age of newborns however, new insights as to why results vary across studies were not apparent.
母体暴露于持久性有机污染物（POPs）与胎儿生长发育改变之间的关联的流行病学研究结果不一致，这表明需要进一步研究。
从格陵兰（572 例）、哈尔科夫（611 例）和华沙（258 例）的接受访谈的孕妇中采集血样，并通过气相色谱-质谱法分析 CB-153 和 p,p'-DDE。获得了 1322 例单胎活产儿的出生体重、胎龄和早产数据。我们使用多元线性回归分析了血清中 POPs 浓度的自然对数与出生体重和胎龄的关系，并使用逻辑回归分析了与早产的关系，同时控制了潜在的混杂因素。
因纽特母亲血清中 CB-153 和 p,p'-DDE 的中位数浓度分别为 105.6 和 298.9，哈尔科夫母亲分别为 27.0 和 645.4，华沙母亲分别为 10.7 和 365.2ng/g 脂质。因纽特母亲血清中 CB-153 浓度增加一个单位，婴儿出生体重降低 59g，胎龄减少 0.2 周。在哈尔科夫和华沙的队列中，观察到的下降虽然具有统计学意义，但并不显著。在因纽特和华沙的队列中，p,p'-DDE 浓度增加一个单位，婴儿出生体重分别降低 39.4g 和 104.3g，胎龄分别缩短 0.2 周和 0.6 周。在哈尔科夫队列中，出生体重下降（-30.5g）不显著，但 p,p'-DDE 浓度增加一个单位，胎龄缩短 0.2 周，具有边缘显著意义。CB-153 和 p,p'-DDE 浓度与早产风险之间无显著关联，但在所有队列中，比值比均高于 1。
母体暴露于 POPs 可能会降低新生儿的出生体重和胎龄，但对于为什么研究结果不一致，我们没有新的见解。
