Ortona L, Antinori A, Tamburrini E, Capelli A, Familiari U, Marano P, Colosimo C
Istituto di Clinica delle Malattie Infettive, Università Cattolica del Sacro Cuore, Roma.
Ann Ital Med Int. 1991 Apr-Jun;6(2):193-202.
The authors review the cases of 40 patients with AIDS who died in 1989, in order to establish the relationships between clinical picture, neuroradiological features and neuropathological findings. Neurological involvement was present in over 75% of the patients, with HIV-related encephalopathy and toxoplasmosis as the most frequent diseases (52.5% and 20.0%). With regard to the cases of AIDS dementia complex (ADC) the authors observed a good correlation between the severity of the clinical manifestations, central nervous system atrophy as observed on computed tomography scan and pathological findings. The survival of AIDS patients with ADC was higher when compared to patients without ADC, suggesting the time-relationship of ADC. AS in the case of toxoplasma encephalitis, a strong relationship between radiological and pathological findings was observed. The presence of toxoplasma encephalitis in patients with radiologic features of healed lesions confirms the need for life-long prophylaxis.
作者回顾了1989年死亡的40例艾滋病患者的病例，以确定临床表现、神经放射学特征和神经病理学发现之间的关系。超过75%的患者有神经系统受累，其中与HIV相关的脑病和弓形虫病最为常见（分别为52.5%和20.0%）。关于艾滋病痴呆综合征（ADC）病例，作者观察到临床表现的严重程度、计算机断层扫描所见的中枢神经系统萎缩与病理结果之间有良好的相关性。与没有ADC的患者相比，患有ADC的艾滋病患者生存率更高，提示了ADC的时间相关性。如同弓形虫脑炎的情况一样，观察到放射学和病理学发现之间有密切关系。具有已愈合病变放射学特征的患者中存在弓形虫脑炎，这证实了终身预防的必要性。
