Chen S
Zhonghua Yi Xue Za Zhi. 1991 Aug;71(8):425-7, 30.
Six cases of Ph1 chromosome negative chronic myelocytic leukemia (CML) were studied. In five cases, the BCR gene configuration was analyzed with a probe covering the major breakpoint cluster region (M-bcr). No M-bcr rearrangement was detected in two cases. On the contrary, the BCR gene was found rearranged in three other patients. The breakpoints of the chromosome 22 were localized within the M-bcr in two cases and in a region upstream the M-bcr in the remaining case. These data suggest that Ph1 negative CML can be divided into two groups according to the BCR gene stattus. The clinical characteristics and pathogenesis of these two groups may be different.
对6例Ph1染色体阴性的慢性粒细胞白血病（CML）进行了研究。在5例中，用覆盖主要断裂点簇区域（M-bcr）的探针分析了BCR基因结构。2例未检测到M-bcr重排。相反，在另外3例患者中发现BCR基因重排。22号染色体的断裂点在2例中定位于M-bcr内，在其余1例中定位于M-bcr上游区域。这些数据表明，Ph1阴性CML可根据BCR基因状态分为两组。这两组的临床特征和发病机制可能不同。
