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A set of 4 nuclear proteins binds to a DNA sequence within the FOS promoter region.

作者信息

Radtke J, Dooley S, Blin N, Unteregger G

机构信息

Institute of Human Genetics, University of the Saar, Hamburg, Germany.

出版信息

Mol Biol Rep. 1991 May;15(2):87-92. doi: 10.1007/BF00364844.

DOI:10.1007/BF00364844
PMID:1660958
Abstract

We investigated DNA-protein-interactions occurring in the promoter region of c-fos using two-dimensional electrophoresis and south-western-blotting. When nuclear extracts from the human glioblastoma cell line HeRoSV were tested for their DNA-binding behaviour to a 650 bp-fragment within the promoter region of c-fos, we found 4 proteins designated as 120/6.6, 75/5.4, 65/6.4 55/5.0 interacting with this fragment. An additional protein 60/6.0 was detected by using a digoxygenine-labelled probe. These observations let us to assume that beside the well characterized SRF and FOS-JUN proteins additional factors recognize the promoter sequence and may play a role in c-fos regulation.

摘要

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本文引用的文献

1
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Nucleic Acids Res. 1983 Mar 11;11(5):1475-89. doi: 10.1093/nar/11.5.1475.
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Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.通过聚丙烯酰胺凝胶电泳研究乳糖阻遏物-操纵基因相互作用的平衡与动力学
Nucleic Acids Res. 1981 Dec 11;9(23):6505-25. doi: 10.1093/nar/9.23.6505.
3
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system.
一种用于定量蛋白质与特定DNA区域结合的凝胶电泳方法：应用于大肠杆菌乳糖操纵子调控系统的组分
Nucleic Acids Res. 1981 Jul 10;9(13):3047-60. doi: 10.1093/nar/9.13.3047.
4
Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor.血小板衍生生长因子可刺激c-fos基因及一个与fos相关基因的表达。
Science. 1984 Nov 30;226(4678):1080-2. doi: 10.1126/science.6093261.
5
A sensitive and rapid gel retention assay for nuclear factor I and other DNA-binding proteins in crude nuclear extracts.一种用于检测粗核提取物中核因子I和其他DNA结合蛋白的灵敏且快速的凝胶滞留分析方法。
Nucleic Acids Res. 1986 Feb 11;14(3):1303-17. doi: 10.1093/nar/14.3.1303.
6
Phosphorylation affects the DNA affinity of the nuclear protein 24/7 from human tumor cells.磷酸化作用会影响来自人类肿瘤细胞的核蛋白24/7与DNA的亲和力。
FEBS Lett. 1988 Aug 29;236(2):367-71. doi: 10.1016/0014-5793(88)80057-7.
7
Rapid detection of DNA-binding factors using protein-blotting and digoxigenin-dUTP marked probes.使用蛋白质印迹法和地高辛配基-dUTP标记探针快速检测DNA结合因子。
Nucleic Acids Res. 1988 Dec 23;16(24):11839. doi: 10.1093/nar/16.24.11839.
8
Different types of modification in c-fos and its associated protein p39: modulation of DNA binding by phosphorylation.c-fos及其相关蛋白p39的不同类型修饰：磷酸化对DNA结合的调节
Oncogene Res. 1987;2(1):19-32.
9
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Mol Cell Biol. 1987 Oct;7(10):3490-502. doi: 10.1128/mcb.7.10.3490-3502.1987.
10
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EMBO J. 1987 Sep;6(9):2711-7. doi: 10.1002/j.1460-2075.1987.tb02564.x.