Iwadate Haruyo, Ohira Hiromasa, Saito Hironobu, Takahashi Atsushi, Rai Tsuyoshi, Takiguchi Junko, Sasajima Tomomi, Kobayashi Hiroko, Watanabe Hiroshi, Sato Yukio
Department of Internal Medicine II, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
World J Gastroenterol. 2006 Apr 7;12(13):2136-8. doi: 10.3748/wjg.v12.i13.2136.
A 46-year-old woman was diagnosed with palmoplantar pustulosis (PPP) at the Department of Dermatology, Fukushima Medical University Hospital in 2000, and was treated with ointment. However, because liver dysfunction developed in 2003, she was referred to our department, where primary biliary cirrhosis (PBC) was also diagnosed on the basis of clinical findings. One year later, at the age of 49, she developed manifestations of Behçet's disease (BD), including erythema nodosum in the lower extremities. Because she had a history of uveitis, recurrent oral ulceration was present, and the HLA typing was positive for B51, BD was additionally diagnosed. Liver function normalized within three months of the start of treatment with ursodesoxycholic acid (UDCA). This is the first case of PBC associated with BD and PPP.
一名46岁女性于2000年在福岛医科大学附属医院皮肤科被诊断为掌跖脓疱病（PPP），并接受了软膏治疗。然而，2003年出现肝功能障碍后，她被转诊至我科，根据临床表现也诊断为原发性胆汁性肝硬化（PBC）。一年后，49岁时，她出现了白塞病（BD）的表现，包括下肢结节性红斑。由于她有葡萄膜炎病史、复发性口腔溃疡，且HLA分型B51呈阳性，故额外诊断为BD。开始使用熊去氧胆酸（UDCA）治疗三个月内肝功能恢复正常。这是首例PBC合并BD和PPP的病例。
