Hayashi Eiji, Tuda Josef, Imada Mihoko, Akao Nobuaki, Fujita Koichiro
Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, Japan.
Southeast Asian J Trop Med Public Health. 2005 Nov;36(6):1399-406.
We performed a serological survey of Toxocara canis infection in junior high school students from three districts in northern Sulawesi. Almost all of the 117 subjects from two rural districts near Manado allowed dogs in their houses, and there was an 84.6% prevalence of T. canis infection in this group. Fifty-three subjects (45.3%) had serum samples with a high titer of specific anti-Toxocara antibody. By contrast, 41 students tested in one urban district showed a 12.2% prevalence. To confirm the clinical symptoms of visceral larva migrans (VML) and ocular larva migrans (OLM) caused by Toxocara, we administered a questionnaire survey, serological liver function tests, and an ophthalmoscopic examination in 34 subjects having high anti-Toxocara antibodies. One rural district showed a high prevalence; 58 out of 71 subjects (81.7%) had a high titer of anti-Toxocara antibodies according to a plate-ELISA test, although none showed clinical signs. Five of these subjects exhibited hypereosinophilia. These results indicated that T. canis infection in northern Sulawesi is latent in many more cases than previously estimated, and suggest that people living in environments polluted by Toxocara eggs become easily infected with T. canis and show a high prevalence of infection.
我们对北苏拉威西省三个地区的初中生进行了犬弓首蛔虫感染的血清学调查。来自万鸦老附近两个农村地区的117名受试者中，几乎所有人家里都养狗，该组犬弓首蛔虫感染率为84.6%。53名受试者（45.3%）的血清样本中特异性抗犬弓首蛔虫抗体滴度较高。相比之下，在一个城市地区测试的41名学生的感染率为12.2%。为了确认由犬弓首蛔虫引起的内脏幼虫移行症（VML）和眼幼虫移行症（OLM）的临床症状，我们对34名抗犬弓首蛔虫抗体水平较高的受试者进行了问卷调查、血清学肝功能测试和眼底检查。一个农村地区的感染率较高；根据酶联免疫吸附试验（plate-ELISA），71名受试者中有58名（81.7%）抗犬弓首蛔虫抗体滴度较高，尽管没有人表现出临床症状。其中5名受试者表现为嗜酸性粒细胞增多。这些结果表明，北苏拉威西省的犬弓首蛔虫感染潜伏病例比之前估计的要多得多，这表明生活在受犬弓首蛔虫卵污染环境中的人很容易感染犬弓首蛔虫，且感染率较高。
